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l'insaisissable (person)
INGÉNIEUR DE CORPS D’ÉTAT SECONDAIRE
May 15 16:49
17 days ago
28 viewers *
French term

LCR panaché

French to English Medical Medical (general) Cytological analysis of CSF
"LCR normal, purulent, lymphocytaire, panaché, hémorragique, ce qui permet d’orienter vers une étiologie bactérienne ou virale"

I know that in terms of a differential count, "panaché" means normal, but this does not seem to be the case for CSF. I believe it means an equal lymphocyte/neutrophil count, but I am not 100% sure, and I cannot find the correct term for this.

Thank you
Proposed translations (English)
4 +2 NLR ratio of 1
4 +2 equal proportion of polymorphonuclear neutrophils and lymphocytes in the CSF
References
Hi Gwynneth, heterogeneous perhaps? Pana...
see

Discussion

Sue Davis May 16:
Neutrophils are one of three types of granulocyte. https://my.clevelandclinic.org/health/body/22016-granulocyte...
Isabelle Villancher May 16:
Neutrophils are granulocytes https://my.clevelandclinic.org/health/body/22016-granulocyte... https://www.sciencedirect.com/topics/neuroscience/neutrophil...
Isabelle Villancher May 16:
"LCR panaché" seems to be characteristic of Tuberculous meningitis (TbM), meningitis caused by Listeria monocytogenes (LM) and fungal meningitis, see here: https://www.e-semio.org/spip.php?page=tableautype12&id_rubri...
Sue Davis May 16:
This site refers to equal proportions of granulocytes and lymphocytes
https://microbiologiemedicale.fr/diagnostic-meningites-analy...
Isabelle Villancher May 16:
"LCR panaché" seems to be characteristic of Tuberculous meningitis (TbM), meningitis caused by Listeria monocytogenes (LM) and fungal meningitis, see here: https://www.e-semio.org/spip.php?page=tableautype12&id_rubri...
Anne Schulz May 16:
While I can't offer a relevant proposal as to the meaning of "panaché", I am not aware of any condition characteristically presenting with an equal proportion of neutrophils and lymphocytes in CSF. In early stages of viral meningitis, equal(ly low) counts may be a transient finding, but this finding does not provide certainty about the nature of the disease.
Sue Davis May 15:
I would add that in English it is usual to omit 'polymorphonuclear' and just use the term 'neutrophils'
philgoddard May 15:
LCR = liquide céphalo-rachidien = cerebrospinal fluid.
http://www.wordreference.com/fren/panaché

Panaché = granulocytes et lymphocytes en proportions proches
http://microbiologiemedicale.fr/diagnostic-meningites-analys...

Proposed translations

+2
19 hrs
Selected

NLR ratio of 1

NLR =Neutrophil-Lymphocyte Ratio
https://emcrit.org/pulmcrit/nlr/

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Note added at 19 hrs (2024-05-16 11:58:41 GMT)
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This refers to equal proportions of granulocytes and lymphocytes. In practice
the majority of granulocytes are neutrophils
https://microbiologiemedicale.fr/diagnostic-meningites-analy...
Panaché = granulocytes et lymphocytes en proportions proches.

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Note added at 19 hrs (2024-05-16 12:01:07 GMT)
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https://www.nature.com/articles/s41598-020-79431-7

The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general population has not been investigated.

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Note added at 19 hrs (2024-05-16 12:01:43 GMT)
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https://www.nature.com/articles/s41598-020-79431-7
The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general population has not been investigated.


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Note added at 19 hrs (2024-05-16 12:02:58 GMT)
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https://www.proz.com/kudoz/7184863#15294511
A normal range of NLR is between 1-2, the values higher than 3.0 and below 0.7 in adults are pathological. NLR in a grey zone between 2.3-3.0 may serve as early warning of pathological state or process such like cancer, atherosclerosis, infection, inflammation, psychiatric disorders and stress.
Peer comment(s):
agree writeaway
7 mins
Thanks writeaway!
agree Yvonne Gallagher
8 mins
Thanks Yvonne!
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Selected automatically based on peer agreement."
+2
34 mins

equal proportion of polymorphonuclear neutrophils and lymphocytes in the CSF

you could always use "panaché" with the description in hard brackets.

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Note added at   40 min (2024-05-15 17:29:51 GMT)
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https://www.atchoum.net/protocoles/c/0/i/27486900/meningite-...



sure it's long-winded, but better to be crystal clear

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Note added at   44 min (2024-05-15 17:33:44 GMT)
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https://www.rcpjournals.org/content/clinmedicine/22/5/396

A predominance of neutrophils in the CSF suggests bacterial meningitis while predominance of lymphocytes suggests viral meningitis. Important exceptions ...

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Note added at   54 min (2024-05-15 17:43:43 GMT)
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I have just thought of "discoloraton"!!

Specific CSF discolorations include the following: Infectious meningitis - Turbid, milky, cloudy CSF samples. Hemorrhage (subarachnoid hemorrhage) or traumatic tap - Pink to orange CSF samples, depending on the concentration of free hemoglobin. Kernicterus - Dark yellow or orange CSF samples with increased bilirubin

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Note added at   57 min (2024-05-15 17:46:29 GMT)
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https://www.larousse.fr/dictionnaires/synonymes/panaché/1527...

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Note added at   21 godz. (2024-05-16 14:46:49 GMT)
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https://www.medecinesfax.org/useruploads/files/52 méningite....

Méningite à liquide clair : * liquide clair. * hypercytose avec formule lymphocytaire ou parfois mixte (une forme panachée évoque une listériose).

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Note added at   22 godz. (2024-05-16 14:51:49 GMT)
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https://www.proz.com/kudoz/french-to-spanish/medical-general...
Peer comment(s):
agree Isabelle Villancher
14 hrs
agree Drmanu49
1 day 2 hrs
Something went wrong...

Reference comments

11 mins
Reference:

Hi Gwynneth, heterogeneous perhaps? Panaché = mixed (see Cambridge dictionary)
"heterogeneous CSF sample composition" https://pubmed.ncbi.nlm.nih.gov/35568819/ "heterogeneous CSF immune-cell repertoire" https://www.sciencedirect.com/science/article/abs/pii/S01655...
Reference:

https://dictionary.cambridge.org/dictionary/french-english/panache

Something went wrong...
9 mins
Reference:

see

https://www.infectiologie.com/UserFiles/File/pilly-etudiant/...

• LCS : typiquement panaché (PNN et lymphocytes en proportions égales), mais parfois purulent ou lymphocytaire. Plu. Antibiothérapie. Traitement préventif.

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Note added at   19 min (2024-05-15 17:08:35 GMT)
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see table 3

https://microbiologiemedicale.fr/diagnostic-meningites-analy...

and definition of "panaché"

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Note added at   24 min (2024-05-15 17:13:10 GMT)
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PMNs include neutrophils, eosinophils, basophils and mast cells. ****In 'normal' CSF, WBCs should be predominantly lymphocytes****.

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Note added at   30 min (2024-05-15 17:19:42 GMT)
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IMPORTANT;

https://geekymedics.com/cerebrospinal-fluid-csf-interpretati...

To understand CSF abnormalities in certain disease states, it is important to understand normal CSF composition.

Normal CSF is acellular. However, up to 5 white blood cells (WBCs) and 5 red blood cells (RBCs) per microlitre (µL) are considered normal after lumbar puncture.

*****White blood cell analysis in CSF usually separates WBCs into lymphocytes and polymorphonuclear leukocytes (PMNs)****.

****PMNs include neutrophils, eosinophils, basophils and mast cells. In ‘normal’ CSF, WBCs should be predominantly lymphocytes. The presence of PMNs in the CSF, particularly neutrophils, suggests bacterial meningitis*****.
Peer comments on this reference comment:
agree Isabelle Villancher
3 mins
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