This question was closed without grading. Reason: Answer found elsewhere
Jan 3, 2023 13:27
1 yr ago
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English term

the HIV accessory protein Vpr

English to Persian (Farsi) Medical Patents
Chimeric Proteins for Cell Targeting and Apoptosis Induction and Methods of Using the same

Field of the Invention

The invention relates to compositions and methods for selectively targeting cells for apoptosis induced cell death.

Background of the Invention

The core protein of West Nile Virus (WNV) has recently been identified as being capable of inducing apoptosis in cell in which it is present. This observation is described in PCT Application Number PCT/US01/31355, which is incorporated herein by reference.

Similarly, the HIV accessory protein Vpr has been identified as being capable of cell cycle arrest and the induction of apoptosis. This observation is described in PCT application PCT/US01/10028, which is incorporated herein by reference.

In addition to these proteins, other proteins such as caspase have been known to induce apoptosis in cells.

There remains a need for compositions and methods which can incorporate the activity of apoptosis inducing proteins into effective compositions useful in methods of eliminating specific cells.
Proposed translations (Persian (Farsi))
5 R پروتئین ویروسی جانبی ایدزی

Proposed translations

6 hrs

R پروتئین ویروسی جانبی ایدزی

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Note added at 6 hrs (2023-01-03 20:06:07 GMT)
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Vpr stands for "Viral Protein R". Vpr, a 96 amino acid 14-kDa protein, plays an important role in regulating nuclear import of the HIV-1 pre-integration complex, and is required for virus replication and enhanced gene expression from provirus in dividing or non-dividing cells such as T cells or macrophages.
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